Bioinformatics MCQs Part 1

• The first bioinformatics database was created by
  A. Richard Durbin
  B. Dayhoff
  C. Michael j.Dunn
  D. Pearson

 

• SWISSPROT protein sequence database began in
  A. 1985
  B. 1986
  C. 1987
  D. 1988

 

• Analyzing or comparing entire genome of species
  A. Bioinformatics
  B. Genomics
  C. Proteomics
  D. Pharmacogenomics

 

• If you were using a proteomics approach to find the cause of a muscle disorder, which of the following techniques might you be using?
  A. creating a genomic library
  B. sequencing the gene responsible for the disorder
  C. developing physical maps from genomic clones
  D.determining which environmental factors influence the expression of your gene of interest annotating the gene sequence

 

• Shotgun cloning differs from the clone-by-clone method in which of the following ways? | Bioinformatics Questions
  A. The location of the clone being sequenced is known relative to other clones within the genomic library in shotgun cloning.
  B. Genetic markers are used to identify clones in shotgun cloning.
  C. Computer software assembles the clones in the clone-by-clone method.
  D. The entire genome is sequenced in the clone-by-clone method, but not in shotgun sequencing.
  E. No genetic or physical maps of the genome are needed to begin shotgun cloning.

 

• The tool for identification of motifs?
  A. COPIA
  B. Pattern Hunter
  C. PROSPECT
  D. BLAST

 

• Gene duplication has been found to be one of the major reasons for genome expansion in eukaryotes. In general, what would be the selective advantage of gene duplication?
  A. If one gene copy is nonfunctional, a backup is available.
  B. Larger genomes are more resistant to spontaneous mutations.
  C. Duplicated genes will make more of the protein product.
  D. Gene duplication will lead to new species evolution.

 

• You see that your lab partner is staring at a colorful Swiss-Prot page. He’s probably trying to
  A. translate a DNA segment into protein.
  B. find out structural and functional information about a protein he’s identified.
  C. determine how many harmful mutations have been reported in a certain gene.
  D. identify an amino acid sequence.

 

• A data base of current sequence map of the human genome is called
  A. OMIM
  B. HGMD
  C. GodenPath
  D. GenCards

 

• BLOSUM matrices are used for
  A. Multiple sequence alignment
  B. Pair wise sequence alignment
  C. Phylogenetic analysis
  D. All of the above

 

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Ans. 1- B , 2-C, 3-B, 4- D, 5-E, 6-A, 7-A, 8-B, 9-C, 10-B