Challenges for Bioinformatics Field

 

1. Education: development of bioinformatics curricula.
2. Determining protein: DNA, protein: RNA, protein: protein recognition codes.
3. Mechanistic understanding of speciation.
4. Development of effective gene ontologies: systematic ways to describe gene and protein function.
5. Accurate ab initio protein structure prediction.
6. Precise models of where and when transcription will occur in a genome (initiation and termination).
7. Precise, predictive models of alternative RNA splicing.
8. Precise models of signal transduction pathways; ability to predict cellular responses to external stimuli.
9. Rational design of small molecule inhibitors of proteins.
10. Mechanistic understanding of protein evolution.